Structure of apolipoprotein C-IIToronto, a nonfunctional human apolipoprotein.

نویسندگان

  • P W Connelly
  • G F Maguire
  • T Hofmann
  • J A Little
چکیده

We previously reported a family with apolipoprotein C-II (apoC-II) deficiency characterized by the presence of a mutant apoC-II, apoC-IIToronto. We now report the purification and primary structure of apoC-IIToronto. The sequence of apoC-IIToronto is identical to that of normal apoC-II from residues 1-68. It differs from residue 69, where Asp69-Gln70-Val71-Leu72-Ser73-Val74- Leu75-Lys76-Gly77-Glu78-Glu79 is replaced by Thr69-Lys70-Phe71-Phe72-Leu73-Cys74. This is consistent with the deletion of a nucleotide in the codon for either Thr68 or Asp69 and a translation reading frame shift.

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عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 84 1  شماره 

صفحات  -

تاریخ انتشار 1987